Store at room temperature away from moisture and heat. You can weight them down with a rock or brick. How to make a natural healing comfrey cream - Simply Comfrey , 43 volunteers with osteoarthritis used either a topical cream containing comfrey, tannic acid, and eucalyptus or a placebo cream 3x/ day for 6 weeks. (3), 147-156. https://doi.org/10.1016/j.jcm.2011.01.003. Complement Ther Clin Pract. A handbook for practice on a scientific basis. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. cup organic safflower oil We cover all you need to know in this article. Comfrey is an herb in the Boraginaceae family and has small purple flowers. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. Comfrey is not recommended for internal use because of the liver damage caused by its pyrrolizidine alkaloids. Dietary Supplements: What You Need to Know. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Can quickly relieve muscle and joint pain. This site uses cookies to improve your experience. View abstract. Wien.Med Wochenschr. Rad. One study followed 142 patients with ankle sprains. However, even if supplements are third-party tested, that doesn't mean they are necessarily safe for all or effective in general. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, not a rate considered harmful for those with healthy livers.10,11, Masters Degree in Toxicology and BSc Hons in Medical Biochemistry. Information from this source is evidence-based and objective, and without commercial influence. Efficacy of a comfrey root extract ointment in comparison to a Diclo-fenac gel in the treatment of ankle distortions: Results of an observer-blind, randomized, multicenter study. When harvesting comfrey or buying from a non-commercial supplier, note that there is variety within the species. #HBTechCareers. This is memorable if you have worked with it, and some use this quality to remember comfreys centuries-long useapplying comfrey over bones, bruises, sprains, and minor wounds with the intention to support mending! . Book your free, one-to-one online consultation with one of our qualified advisors. Effects of Symphytum ointment on muscular symptoms and functional locomotor disturbances. In a randomized multicenter study with 164 ankle sprain patients, swelling and pain were improved more successfully using a comfrey root extract compared to a diclofenac gel (Predel et al., 2005). Staiger, C. Comfrey root: from tradition to modern clinical trials. It is not certain whether comfrey is effective in treating any medical condition. Comfrey has long been used in folk traditions for bruising and abrasions. More research is needed. The leaves and stems of comfrey contain pyrrolizidine alkaloids that can cause toxic damage if ingested in excess (Ulbricht, 2010). Wang YP, Yan J, Fu PP, Chou MW. This could change the effects and side effects of comfrey. Comfrey oil should be applied topically to parts of the body where you have muscular pain or discomfort. 2017;65(1):363-373. doi:10.1002/hep.28813. Symphytum officinale), store bought or via recipe, above. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Navarro VJ, Khan I, Bjrnsson E, Seeff LB, Serrano J, Hoofnagle JH. Medicine makers would bind comfrey leaves and roots in poultices, then apply those poultices to the skin to treat injuries. Limited trials have evaluated the effectiveness of alkaloid-free preparations for external use; however, these studies did not examine how much liver damage occurred in patients. hollandandbarrett.ie is a trading name of Holland & Barrett Retail Limited. 2 cups organic, unrefined coconut oil Phytother Res. Comfrey contains chemicals that cause serious liver damage when taken by mouth. British journal of sports medicine, 44(9), 637-641. https://doi.org/10.1136/bjsm.2009.058677, Grube, B., Grnwald, J., Krug, L., & Staiger, C. (2007). Wound-healing effects of a symphytum herb extract cream (. Soaked foot in warm water with a few leaves of comfry. As we are constantly reviewing and developing our products to meet our consumer needs, consumers, particularly those that suffer from allergies and intolerances, should always check product labelling, warnings, and directions provided with the product that is delivered, prior to use or consumption. Efficacy and tolerance of a comfrey root extract (Extr. View abstract. And topical capsaicin cream may help to relieve pain temporarily. Regarding its antioxidant, antilipoperoxidant, antiinflammatory, and cytotoxic properties. Modern science suggests that the ancients were correct in believing comfrey helps to heal woundsand relieve pain.3,4 In this article, well explain where comfrey comes from, comfrey oils remarkable health benefits and how to use it at home. However, comfrey can also contain toxic substances called pyrrolizidine alkaloids that cause liver damage, cancer, and death. In another study, participants with ankle sprains received either comfrey root extract cream or diclofenac gel, a nonsteroidal anti-inflammatory drug (NSAID). To make this recipe, first, you must prepare the comfrey root tincture. Osteoarthritis.Cartilage. Arzneimittelforschung. It contains chemicals that are poisonous. When considering the use of herbal supplements, seek the advice of your doctor. Avoid use. doi:10.1002/14651858.CD010538, Smith DB, Jacobson BH. Grube, B., Grunwald, J., Krug, L., and Staiger, C. Efficacy of a comfrey root (Symphyti offic. Its long, lance-shaped leaves can be up to 1 foot in length closer to the bottom of the stem and are shorter higher up the stem. comfrey: [noun] any of a genus (Symphytum) of perennial herbs of the borage family with coarse hairy entire leaves and flowers in one-sided racemes. Healthy adults: massage about 1 teaspoon of cream into a local area up to 4x/day for up to 2 weeks. COMFREY Reviews and User Ratings: Effectiveness, Ease of Use - WebMD When buying commercial brands, seek those that have had the pyrrolizidine alkaloids removed, if possible. This is memorable if you have worked with it, and some use this quality to remember comfreys centuries-long useapplying comfrey over bones, bruises, sprains, and minor wounds with the intention to support mending! Whether youre familiar with it or not, this unusual herbal remedy is definitely worth knowing more about. The FDA has recommended that all comfrey products that are taken by mouth be removed from the market. Retrieved from https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=295, Predel, H. G., Giannetti, B., Koll, R., Bulitta, M., & Staiger, C. (2005). We comply with the HONcode standard for trustworthy health information. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Glass bowl with a lid Choose organically grown comfrey when possible. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. The plant has a long history in folk and ancient herbal treatments before comfrey is . Using different formulations together increases the risk of an overdose. Pyrrolizidine alkaloids are very toxic to the liver and are also carcinogenic (cause cancer). In a randomized, double-blind, placebo-controlled trial, 220 patients with knee osteoarthritis used either a commercial topical comfrey root extract or a placebo. Drug class: Herbal products. All rights reserved. This perennial can grow up to 4-feet tall. Aust.Fam.Physician 2008;37(4):235-236. This makes quite a thick rich cream good for a body cream and an all healing cream . Stop using comfrey and call your healthcare provider at once if you have: liver problems-- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Comfrey is traditionally used for the symptomatic treatment of minor sprains and bruises and is also known for its healing properties Customer Reviews Ingredients Full ingredients Brassica Campest is Seed Oil (Rapeseed Oil), Symphytum Officinale Herb (Comfrey Herb), BHA, Eucalyptus Globulus Leaf Oil (Eucalyptus Oil). Transfer the cooled oil and butter mixture to a standing electric mixer or blender. Comfrey: Uses, Risks, and Takeaways - Healthline Additionally, use on a deep cut may encourage healing of the outer skin the preparation comes in direct contact with faster than the deeper tissue, leading to abscess. Hybrids and other species may have a similar appearance but could have significantly different amounts of the toxic pyrrolizidine alkaloids (Kucera et al., 2018). While larger and more studies are needed to fully determine safety and effectiveness, short term topical application of comfrey may give you peace of mind, relief, and support while you rest and heal, following any additional advice from your physician. Many of those following the folk use of comfrey up to present-day think so. Registered office: Samuel Ryder House, Barling Way, Nuneaton, Warwickshire CV10 7RH. View abstract. Comfrey's original name, knitbone, derives from the external use of poultices of its leaves and roots to heal burns, sprains, swelling, and bruises. Ther Drug Monit 2001;23:698-708. However, further well-designed studies are needed. First, make the comfrey root tincture by combining the dried comfrey root and alcohol in a sterilized, dry, glass pint jar. comfrey cream holland and barrett. Wien.Med.Wochenschr. 2 Comfrey cream contains several active components (substances). Please read the Topical Use Safety section of this article (above) before using. Phytomedicine 2005;12(10):707-714. Copyright Holland & Barrett Retail Limited, 2022. Food and Drug Administration. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial. All rights reserved. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. As a Licensed Massage Therapist for fifteen years, I have noticed that back pain can be caused by a variety of reasons and can be very debilitating. Follow all directions on the product label and package. Its ready when the mixture has solidified somewhat and has a cloudy, creamy, and slightly runny consistency. Braz J Biol. Newer Post Older . State Level Environment Impact Assessment Authority, Jharkhand As a Licensed Massage Therapist, I have personally made this comfrey cream recipe multiple times and given jars to my clients. Nutrition C for FS and A. Buy 1 get 1 Half Price on Vitamins & Supplements, Popular Vitamins & Supplements Subscriptions, Buy 1 get 1 Half Price gut health supplements, Guide to sleeping better natural sleeping remedies, Living in the now, gut health & mental wellbeing, The thing that makes you different makes you special, Bhupesh Panchal, Senior Regulatory Affairs Associate, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908267/, http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx, http://www.sciencedirect.com/science/article/pii/S0965229913001672, http://www.ncbi.nlm.nih.gov/pubmed/22887778, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363250/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631335/, https://pubmed.ncbi.nlm.nih.gov/22887778/, https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-symphytum-officinale-l-radix_en.pdf, http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000234. The warm weather has a way of encouraging us to get outside and move our bodies more. Koll, R., Buhr, M., Dieter, R., Petrowicz, O., Gianetti, B., and Wagener, S. Wirksamkeit und Vertraglichkeit von Beinwellextrakt (Extr. Comfrey oil is a herbal oil that moisturises skin, and that's been used as a healing herb for a long time. Understand comfreys contraindications before using it. If you're considering using the cream, consult your healthcare provider first. J Toxicol Environ Health B Crit Rev. Dosage: How Much Comfrey Cream Should I Use? An Evidence-Based Reference. Symphyti) in the treatment of ankle distorsions: Results of a multicenter, randomized, placebo-controlled, double-blind study. comfrey cream holland and barrettfeathered friend questions and answers. The efficacy and safety of comfrey. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Comfrey can kill. Efficacy of a comfrey root (Symphyti offic. Huxtable RJ, Awang DV. Predel, H. G., Giannetti, B., Koll, R., Bulitta, M., & Staiger, C. (2005). Symphyti) in the treatment of ankle distorsions: Results of a multicenter, randomized, placebo-controlled, double-blind study. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Avoid with medications that induce CYP3A4 or are hepatotoxic (Natural Medicines, 2020). Consult your healthcare provider before using comfrey cream. Of course, more research is needed to validate efficacy and safety. Comfrey is a fast-growing plant whose leaves and roots have been used historically for wound healing and other conditions. This recipe is contraindicated for small children and those with certain medical conditions. Herbal medicine for low back pain: A Cochrane review. As we are constantly reviewing and developing our products to meet our consumer needs, consumers, particularly those that suffer from allergies and intolerances, should always check product labelling, warnings, and directions provided with the product that is delivered, prior to use or consumption. Results of an observational study of patients]. 2013;5(5):CD010538. Other alternative therapies may help to ease the pain. Other prescription medicines that may harm the liver include: Some supplements may also harm the liver, including: It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A large review released in 2013 about the medicinal uses of comfrey stated: It is clinically proven to relieve pain, inflammation and swelling of muscles and joints in the case of degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after . Set on a sunny windowsill and shake once a day for 2-4 weeks. 2758955. 2017;83:1-4. View abstract. Avila C, Breakspear I, Hawrelak J, Salmond S, Evans S. A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale). Consult your healthcare provider before using. Published 2021 Sep 20. doi:10.1590/1519-6984.249209, Frost R, MacPherson H, O'Meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). Discontinue use if a rash develops. , meaning to grow together. of India has issued Environment Impact Assessment EIA Notification dated 14th September, 2006 for according Environment Clearance(EC) to 8 categories of industries/projects by the Ministry of Environment & Forests, Govt. Copyright Holland & Barrett Limited 2023. View abstract. 1.35 Fl Oz. Poisons Legislation Circular 3-22-1993;60. Jedlinszki N, Balzs B, Csnyi E, Csupor D. Penetration of lycopsamine from a comfrey ointment through human epidermis. Call your doctor if the condition you are treating with comfrey does not improve, or if it gets worse while using this product. Penetration of lycopsamine from a comfrey ointment through human epidermis. Complementary Health Approaches for Chronic Pain: What the Science Says. Comfrey is generally considered unsafe, with numerous toxicological effects in animals and humans. Pharmazie 1995;50:83-98. (2018). A critical scoping review of external uses of comfrey (Symphytum spp.). The Comfrey Ointment that I have been using is to be used only for sprains and bruises. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. Barna, M., Kucera, A., Hladicova, M., and Kucera, M. [Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study]. Arzneimittelforschung. NIH Office of Dietary Supplements. Information offered on Herbal Academy websites is for educational purposes only. Phytomedicine. Comfrey cream combines ingredients like oils or water and glyceryl stearate with Symphytum officinale (comfrey) extracts. Mosby Elsevier. They help us to understand how people use the website and give us the ability to provide targeted marketing to you. Version: 5.01. Ulbricht, C. (2010). Comfrey is avoided on cuts or puncture wounds for this reason. What are the benefits of using it? 2013;163(3-4):58-64. Contact your doctor or pharmacist if you have any questions before use. Comfrey flowers are bell-shaped and purple, pink, or pale yellow in color, and it has a dark taproot. Phytother.Res 2012;26(10):1441-1448. Bagheri Z, Azizi A, Oshvandi K, Mohammadi Y, Larki-Harchegani A. Wichtl, M. (2004). Finally, well warn of any side effects associated with comfrey oil. It can grow up to 5 feet tall. Penetration of lycopsamine from a comfrey ointment through human epidermis. 1 It's found in Europe, Asia, and North America. Additionally, there is scientific research demonstrating comfreys effectiveness at soothing muscle and joint pain, some of which are highlighted in this post. Sowa I, Paduch R, Strzemski M, et al. View abstract. It's typically only used in small amounts for a very short period. Check regularly, but it should take about six weeks for all the leaves to break down into a thick, black liquid. A multi-center, randomized, double-blind, controlled clinical trial was conducted with 161 patients having acute lower back pain. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: Results of a double-blind, randomised, bicenter, placebo-controlled trial. Drug-induced liver injury. randomized double-blind study of 278 patients with fresh abrasions, a. topical preparation containing a 10% comfrey leaf extraction applied for 2-3 days reduced wound healing time of adults and children without side effects (Barna et al., 2012). WebMD does not provide medical advice, diagnosis or treatment. Available for Android and iOS devices. Like any new treatment, discontinue use if any irritation occurs. These include allantoin, rosmarinic acid, and others. After the tincture is made, then you can whip up the fabulous joint and muscle cream! A handbook for practice on a scientific basis. Comfrey is considered likely unsafe to use if you are nursing a baby. (2013). These side effects may be common or severe. Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. For External Use only Do not use if you are sensitive to any of the ingredients. Children, who suffer from these injuries the most, are statistically unlikely to have adverse reactions to comfrey oil when used on scrapes.5, When comfrey was applied topically to animals above where theyd suffered bone fractures, their bones healed at a much-improved rate than animals who hadnt been treated with comfrey.6, Leg ulcers are uncomfortable, prone to infection, and can take a long time to heal. Using a supplement like comfrey may have potential side effects. Comfrey Cream Recipe for Achy Joints and Muscles - Herbal Academy Select a condition to view a list of vitamins. Stickel F, Seitz HK. cbd cream holland and barrett for pain relief Comfrey. After the tincture is made, then you can whip up the fabulous joint and muscle cream! To Use. Arzneimittelforschung, 62(06), 285-289. https://doi.org/10.1007/s10354-007-0474-y, Giannetti, B. M., Staiger, C., Bulitta, M., & Predel, H. G. (2010). Giannetti, B. M., Staiger, C., Bulitta, M., and Predel, H. G. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. Comfrey is an herb in the Boraginaceae family and has small purple flowers. Quis autem velum iure reprehe nderit. Discard after a year or according to labeling. Comfrey cream The ointment has a very mild herbal fragrance and is soothing on application. 12 drops peppermint (Mentha piperita) essential oil Be sure to choose organic carrier oils and essential oils when possible. (21), 498-507. https://link.springer.com/article/10.1007/s10354-004-0114-8, Natural Medicines (2020). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. By Megan Nunn, PharmD Looks like you may need to upgrade your browser We're sorry, we no longer support the web browser that you are using Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Not all possible interactions are listed in this product guide. Researchers have investigated the effects of comfrey cream on several health conditions. This soothing blend of herbal oils contains Comfrey (also known as Knitbone) and Eucalyptus Oil. Frost R, O'meara S, Macpherson H. The external use of comfrey: a practitioner survey. Avoid using comfrey extracts on broken skin or open wounds. Comfrey has been claimed to heal gastric ulcers and hemorrhoids, and to suppress bronchial congestion and inflammation. Yield: Approximately 5 cups of whipped lotion. Potter's Herbals Comfrey Ointment for Minor Sprains and Bruises New South Wales Health, Australia. The participants were assigned three weeks of treatment with two grams of either comfrey ointment or a placebo three times a day. This item: Terry Naturally Traumaplant Comfrey Cream - 1.76 oz (50 g) - Non-Staining Topical Botanical, Free of Toxic Pyrrolizidine Alkaloids (PAs) & Parabens - for External Use Only $20.76 ($11.80/Ounce) Dr. Christopher's Comfrey Ointment, 2 Ounce $11.99 ($6.00/Ounce) Dr Christopher's Formula Complete Tissue and Bone Ointment, 4 Ounce Additionally, because its alkaloids are absorbed through the skin, use of comfrey as a poultice should not exceed an exposure of 100 mcg/day of the alkaloids. Comfrey oil is made by infusing the leaves and roots of a comfrey plant with a neutral oil. We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. Jedlinszki, N., Balzs, B., Csnyi, E., & Csupor, D. (2017). Written by Cerner Multum. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., Giannetti, B., Klingenburg, S., and Staiger, C. Efficacy and tolerance of a comfrey root extract (Extr. View abstract. Join rewards for life today and we'll give you 300 points worth 3.00. Homeopathy. A later study of 133 peoplefound some evidence that a topical combination of comfrey extract and tannic acid led to reduced knee pain. This perennial can grow up to 4-feet tall. You should never ingest comfrey by mouth. View abstract. Potters Herbal Comfrey Oil is a soothing aromatic herbal massage oil. A significant reduction in pain was observed in the groups using the comfrey product. Save the remaining liquid alcohol portion. View abstract. DOI:10.1211/PJ.2021.1.69803. It has bell-shaped red-violet or yellowish flowers. If your healthcare provider recommends it, make sure to use it on intact skin for a small amount of time, and be careful that infants do not ingest it. Turley, A. J. and Muir, D. F. ECG for physicians: a potentially fatal case of mistaken identity. The combination of Vitamin E, Wheat Germ oil and Rice Bran oil makes this cream perfect for your daily hydration needs. 2004;11(6):470-477. 12 drops juniper berry (Juniperus communis) essential oil The first European settlers of America considered comfrey so indispensable, they carried it on their journey across the Atlantic in the 1600s.2. British Homeopathic Journal, 90(01), 21-28. https://doi.org/10.1054/homp.1999.0460. View abstract. Discontinue use if a rash appears. 2011;10(3):147-56. doi:10.1016/j.jcm.2011.01.003, Laslett LL, Quinn SJ, Darian-Smith E, et al. 4.3 4.3 out of 5 stars (225) $19.95 $ 19. The ankle swelling decreased by 79.5% in the comfrey root group and 69.4% in the diclofenac group. We cover all you need to know in this article. Amendments to the poison list. Comfrey - The Lost Herbs J Ethnopharmacol 1995;48(2):61-76. View abstract. We currently have no information for COMFREY overview. Comfrey cream combines ingredients like oils or water and glyceryl stearate with Symphytum officinale (comfrey) extracts. Experts suggest not using comfrey cream for longer than ten days in a row. Natural Standard. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial. 2016 Jan;41(2):116-33. doi:10.1097/01.brs.0000249525.70011.fe. Comfrey Cream: Uses, Benefits, Side Effects, Dosage - Verywell Health Symphyti) bei Sprunggelenks-distorsionen. July 6, 2001. Anotherstudy found that comfrey ointment was superior to placebo in relieving pain and stiffness in osteoarthritis. Heard about essential oils but not quite sure about what they can do for you? Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: Comfrey is considered likely unsafe to use during pregnancy. Symphytum officinale L., dermal use (Flexagile cream)]. As the consistency thickens some more, turn the mixer up a little bit more. Eucalyptus oil is used externally to stimulate blood flow. You may report side effects to FDA at 1-800-FDA-1088. Facebook; Twitter; Pinterest; Related Posts. In a study of 712 children with superficial wounds, applying a 25% comfrey cream for one week or up to two weeks (2-4x day) offered a strong benefit to risk ratio (Kucera et al., 2018). The roots and leaves of the comfrey plant have medicinal properties. Please read the Topical Use Safety section of this article (above) before using. Further study is needed to confirm these results. Smith DB, Jacobson BH. Complement Ther Med. This article discusses the uses and benefits of comfrey cream. J Chiropr Med. Also, avoid use for more than two weeks or excessive concentrations containing more than 100 mcg of pyrrolizidine alkaloids (Wichtl, 2004 & Ulbricht, 2010). Some medications can also harm the liver. Copyright Holland & Barrett Retail Limited, 2022. Hybrids and other species may have a similar appearance but could have significantly different amounts of the toxic pyrrolizidine alkaloids (Kucera et al., 2018). 16 Rewards for Life points with this purchase. Heat oil in double boiler gently then add beeswax until it melts. Wien Med Wochenschr. Tolerability and effectiveness of an antitrauma cream with comfrey herb extract in pediatric use with application on intact and on broken skin. Comfrey - Memorial Sloan Kettering Cancer Center Bhupesh started his career as a Clinical Toxicologist for Public Health England, advising healthcare professionals all around the country on how to manage clinical cases of adverse exposure to supplements, pharmaceuticals, cosmetics, industrial chemicals and agricultural products.