One is the patient's basic red cell population; the other is a second population with distinct morphological features. ABNORMAL MORPHOLOGY OF RED BLOOD CELL When a blood smear is inspected for abnormal morphology, two criteria must be met. SPECIMEN ... Platelet Morphology** Giant Platelets Present Large Plt Present Agranular (gray) Plt Present Platelet Satellitosis Present ** Above morphological characteristics are to be indicated as present if noted on smear. The small RBC without central pallor would represent normal feline erythrocytes. Nucleated red blood cells. Basophilic Stippling Red Blood Cell Morphology & Blood Parasites Erythrocytes -The function of a red blood cell is to to distribute oxygen carried by hemoglobin -Most red blood cells do not have a nucleus except in birds, reptiles, and fish -Most are round except for birds, Red Blood Cell Maturation. ... - present in iron-deficiency & idiopathic myelofibrosis - abnormal spectrin & protein in RBC membrane. Red Blood Cell Morphology Red blood cells (erythrocytes) are biconcave disks with a diameter of 7-8 microns, which is similar to the size of the nucleus of a resting lymphocyte. Giant platelets have a diameter greater than 7 microns (larger than a normal red blood cell). There are also changes that occur in red blood cells that can give us clues as to underlying diseases. Head, body and tail. Evidence of haemolysis may be present (eg. It often occurs alongside iron-deficiency anemia. Clinical Utility: A Pathologist referral will be performed if established criteria are present. Sample To assess RBC morphology make fresh smear and smears from the blood in EDTA. PowerPoint is the world's most popular presentation software which can let you create professional RED BLOOD CELL MORPHOLOGY powerpoint presentation easily and in no time. Used to diagnose and monitor therapy for diagnoses such as iron-deficiency anemia. This condition is reversible, and more often than not, it is a side effect of the EDTA anticoagulant coating in the vacutainer used to collect to blood to prevent it from clotting. Important preliminary findings include agglutination, polychromasia (reticulocytosis), target cells (liver disease or alcohol), and a dual population (MDS or post transfusion). •Numerous target cells are present in this patient with hemoglobin E and beta thalassemia trait. 3-Tail Examples of unacceptable smears. Red blood cells are the major cellular component of blood. Spherocytosis. Agglutination can falsely increase the MCV. They may also be present in myeloproliferative neoplasms, myelodysplasia, and some congenital thrombocytopenia syndromes, including Bernard-Soulier syndrome and MYH9 -related … Mature red blood cells are biconcave discs that lack nucleus and most cell organelles such as lysomes, endoplasmic reticulum and mitochondria. Similar to the RBC indices, it is determined by automated cell counting instruments and is used to predict the degree of red blood cell size variation, known as anisocytosis. Pronormoblast (Rubriblast, Proerythroblast) Basophilic Normoblast (Prorubricyte, Basophilic Erythroblast) Polychromatic Normoblast (Rubricyte, Polychromatic Erythroblast) Orthochromic … Normal mature RBC are biconcave, round discs that are about 6 – 8 in diameter, which is only slightly smaller than the normal small mature lymphocytes ( about 6 – 10 in diameter). Diameter – 7- 8µm Red blood cell morphology is species-dependent. In spite of this, and the continual standardization of test result formats, publications of reference guidelines, the improvements of laboratory (lab) technologies, and the advancements in hematology instrumentations 1-7, the methods of reporting or grading abnormal red blood cell morphology (RBC‐M) still vary among laboratories everywhere 8, 9. Precautions A well- made smear is needed. Quickly memorize the terms, phrases and much more. Morphology of platelets and platelet count Presence of parasites What is the normal RBC morphology. RBC morphology 3. Target cells, or codocytes, have an excess of cell membrane relative to cell volume. 1. RBC Count, Indices, Morphology, and Inclusions is a topic covered in the Davis's Lab & Diagnostic Tests.. To view the entire topic, please sign in or purchase a subscription.. (poly- refers to many, and -chromasia means color. For example, small Heinz bodies are commonly seen in the blood of cats without causing anemia. Macrocytosis is a term used to describe red blood cells that are larger than normal. about 4-6 millions/mm 3. However, variable abnormal erythrocyte morphology is found in various pathological conditions: Anisocytosis is a condition in which the red blood cells are not even in size. Polychromasia is a disorder where there is an abnormally high number of immature red blood cells found in the bloodstream as a result of being prematurely released from the bone marrow during blood formation. The MCV may be increased (macrocytosis) or decreased (microcytosis). It can be caused by various anemias, such as iron deficiency where the cells will be smaller than normal pernicious anemia, where cells are larger than normal (B12 deficiency). RBC indices are quantitative indicators of RBC morphology. Cram.com makes it easy to get the grade you want! Figure 4-26. RBC- Morphology. Large platelets can be seen when platelet turnover is increased (as in immune thrombocytopenic purpura). Link: CBC Reference Ranges ... Jones, Kathy W. "Evaluation of Cell Morphology and Introduction to Platelet and White Blood Cell Morphology." The bottom image on the right illustrates the two distinct peaks that are observed on the RBC histogram from the automated hematology analyzer. Before we start with the abnormal morphologies, let’s talk about normal morphology of Red Blood Cells. 4. In normal red blood cells , there is an area of central pallor that measures approximately 1/3 the diameter of the cell. 2 Casanova et al were able to ... RBC indices and morphology. In man and in all mammals, erythrocytes are devoid of a nucleus and have the shape of a biconcave lens. It’s an indication of red blood cells being released prematurely from bone marrow during formation. RBC and WBC morphology. h-comer24. I … Learn vocabulary, terms, and more with flashcards, games, and other study tools. Learn more about RBC in urine, and what results from a urine sample might mean, here. If both macrocytes and microcytes are present, the MCV may be normal. Red Blood Cell Distribution Width (RDW) RDW is the coefficient of variation or standard deviation of the MCV. In β-thalassemias, the examination of a peripheral blood (PB) smear may provide relevant clues to initial diagnosis. 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