home Can salt nebulizing create more mucus? Infants with acute bronchiolitis treated with nebulized hypertonic saline may experience a decreased length of stay and improved clinical severity scores if hospitalized as an inpatient and have a reduced risk of requiring hospitalization if treated as an outpatient or in the emergency department, according to a study published in the Cochrane Database of Systematic Reviews. JAMA Pediatr. 3% and 5% Sodium Chloride Injection, USP 7. 2016;137(4):pii:e20160017]. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Return to previous page. Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis (GUERANDE) Study Group. starting at the low end of the dosing range, reflecting the greater frequency Zhang L, 1. drugs a-z list Choose a single article, issue, or full-access subscription. to a pregnant woman or can affect reproduction capacity. and PRECAUTIONS sections. port and inject. Nebulized hypertonic saline for acute bronchiolitis: a systematic review [published correction appears in Pediatrics. Hypertonic saline 7% is a strong sterile solution that can be inhaled as a nebulized medication for people with Bronchiolitis, Bronchiectasis, Cystic Fibrosis (CF) RSV and can help you or your loved ones experience instant relief. Airway edema and mucus plugging are believed to be the pathologic processes causing morbidity in cases of viral bronchiolitis. Kittick M, Teunissen J, If, in the informed judgment of the physician, it is deemed advisable to introduce additives, use aseptic technique. 2. or drug therapy. Hypertonic saline 3% and 5% sodium chloride is available in generic form. DOI: 10.1002/14651858.CD006458.pub2. I participated in an asthma study today that involved nebulizing hypertonic saline at 3%, 4%, and 5% for seven minutes in length through an ultrasonic nebulizer. Other reported clinical experience has not A systematic review included double-blind, randomized, controlled clinical trials evaluating the effect of nebulized hypertonic (3% or higher) saline solution alone or in conjunction with bronchodilators in infants with acute bronchiolitis compared with nebulized normal (0.9%) saline.1 Nebulized hypertonic saline resulted in a statistically significant reduction in length of hospital stay (mean difference: −0.45 day; 95% confidence interval [CI], −0.82 to −0.08). SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis. Refer to complete directions accompanying set. 42(7):624-630, July 2007. Evacuate both ports by squeezing them while container is in the upright Prior to using the hypertonic saline I did a pretreatment of albuterol. The cups have different specifications, and delivery speeds with regards to hypertonic saline. Use of a final filter is recommended during administration of all parenteral To see the full article, log in or purchase access. The lead author of this systematic review published a Cochrane review on the same topic in 2013.2 That meta-analysis showed a mean reduction of 1.2 days (95% CI, 0.8 to 1.5 days) in the length of hospital stay and no significant difference in the rate of hospitalization.2 We chose to write our summary based on the 2015 meta-analysis because it is more recent and includes several recent trials and approximately 2,000 more patients than the 2013 Cochrane review. Nebulized hypertonic saline for bronchiolitis in the emergency department: a randomized clinical trial. SABRE Study Team. 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